Cyclic Peptides. XXIII. Synthesis of Retro-Enantio-AM-Toxin I
نویسندگان
چکیده
منابع مشابه
Straightforward synthesis of cyclic and bicyclic peptides.
Cyclic peptide architectures can be easily synthesized from cysteine-containing peptides with appending maleimides, free or protected, through an intramolecular Michael-type reaction. After peptide assembly, the peptide can cyclize either during the trifluoroacetic acid treatment, if the maleimide is not protected, or upon deprotection of the maleimide. The combination of free and protected mal...
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Inhibition of binding of extracellular matrix (ECM) proteins fibrinogen and vitronectin to the IIbβ3 and vβ3 integrins, respectively, is of great pharmaceutical interest. Both receptors recognize the RGD tripeptide sequence, which is present in these natural ligands. The development of antagonists for these integrins is therefore often based on this tripeptide unit and several cyclic RGD pept...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1986
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.59.2651